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CBP Faculty - Peter F. Drain, Ph.D.

Peter F. Drain, Ph.D.
Associate Professor
Tel: 412-648-9412
Fax: 412-648-8792
drain@pitt.edu
PubMed pub. listing
CBP Research Group(s):

Regulation of Intracellular Signaling and Gene Expression
CBMP Graduate Program Groups:
Genomics, Proteomics and Metabolomics

Research Interest


Publications
  1. D.J. Michael, W. Xiong, X. Geng, P. Drain, and R.H. Chow. 2007. Human Insulin Vesicle Dynamics During Pulsatile Secretion. Diabetes 56:1277-1288.
  2. X. Geng, L. Li, R. Bottino, A.N. Balamurugan, S. Bertera, . Densmore, A. Su, Y. Chang, M. Trucco, P. Drain. 2007. Antidiabetic sulfonylurea stimulates insulin secretion independently of plasma membrane KATP channels. Am. J. Physiol. Endocrinol. Metab. 293:E293-E301.
  3. K. Nakahira, H.P. Kim, X. Geng, A. Nakao, N. Murase, P. F. Drain, Wang X, Shaw-Fang Yet S-F, Nabel EG, Takahashi T, Morita K, Choi, AMK. 2006. Carbon monoxide differentially inhibits TLRs signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. The Journal of Experimental Medicine 203:2377-89.
  4. L. Li, X. Geng, M. Yonkunas, A. Su, E. Densmore, P. Tang, and P. Drain. 2005. Ligand-Dependent Linkage of the ATP Site to Inhibition Gate Closure of the KATP Channel, J. Gen. Physiology 126: 285-299.
  5. Drain, P., X. Geng, and L. Li. 2004. Concerted gating mechanism underlying KATP channel inhibition by ATP. Biophysical J. 86:2101-2112.
  6. Geng, X., Li, L., Watkins, S., Robbins, P.D., and Drain, P. 2003. The Glucose-Regulated Pancreatic KATP Channel Is Targeted to the Insulin Secretory Granule. Diabetes 52:767-776.
  7. Li, L., X. Geng, and P. Drain. 2002. Open state destabilization by ATP occupancy is mechanism speeding burst exit underlying KATP channel inhibition by ATP. J. Gen. Physiol. 199:105-116.
  8. Watkins, S., Geng, X., Li, L., Papworth, G., Robbins, P.D., and Drain, P. 2002. Image Secretory Vesicles by Fluorescent Protein Insertion into Propeptide Rather Than Mature Secreted Peptide. Traffic 3: 461-471.
  9. Li, L., J. Wang, and P. Drain. 2000. I182 of Kir6.2 Is Closely Associated With Ligand Binding Steps In The Mechanism By Which ATP Inhibits the KATP Channel. Biophysical J. 79: 841-852.
  10. Drain, P., L. Li, and J. Wang. 1998. KATP channel inhibition by ATP requires distinct functional domains of the cytoplasmic C terminus of the pore-forming subunit. Proc. Natl. Acad. Sci. USA 95: 13953-13958.