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CBP Faculty - Rebecca P. Hughey, Ph.D.

Rebecca P. Hughey, Ph.D.
Professor
Primary Appointment: Medicine, Renal-Electrolyte
Tel: 412-383-8949
Fax: 412-383-8956
hugheyr@pitt.edu
PubMed pub. listing
Hughey Webpage
CBP Research Group(s):
CBMP Graduate Program Groups:
Cell Communication, Signaling and Ion Channel Biology
Membrane Traffic of Proteins and Lipids

Research Interest
Publications
  1. Carattino, MD, Passero, C, Steren, CA, Maarouf, AB, Pilewski, JM, Myerburg, MM, Hughey, RP and Kleyman, TR. Identification and characterization of an inhibitory domain in the alpha subunit of the epithelial sodium channel. Am J Physiol Renal Physiology Am J Physiol Renal Physiology 294:F47-F52, 2008.
  2. Lowry, MH, McAllister, BP, Jean, JC, Brown, LAS, Hughey, RP, Cruikshank, WW, Amar, S, Luce,y E, Wight, TN and Joyce-Brady, M. Lung Lining Fluid Glutathione Attenuates IL-13 Induced Asthma. Am J Respir Cell Mol Biol 38(5):509-16, 2008.
  3. Mueller, GM, Kashlan, OB, Bruns, JB, Maarouf, AB, Aridor, M, Kleyman, TR and Hughey, RP, Epithelial sodium channel exit from the endoplasmic reticulum is regulated by a signal within the carboxyl cytoplasmic domain of the alpha subunit, J Biol Chem 282:33475-33483, 2007.
  4. Bruns, JB, Carattino, MD, Sheng, S, Maarouf, A.B., Weisz, OA, Pilewski, JM, Hughey*, RP and Kleyman, TR. Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma subunit. J Biol Chem 282: 6153-60, 2007 (*corresponding author)
  5. Kinlough, CL, McMahan, RJ, Poland, PA, Bruns, JB, Harkleroad, KL, Stremple, RJ, Kashlan, OB, Weixel, KM, Weisz, OA and Hughey, RP MUC1 recycling is dependent on its palmitoylation. J. Biol. Chem. 281: 12112-22, 2006.