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CBP Faculty - Shivalingappa Swamynathan, Ph.D.

Shivalingappa Swamynathan, Ph.D.
Associate Professor
Primary Appointment: Ophthalmology
Tel: 412-802-6437
Fax: 412-647-5880
swamynathansk@upmc.edu
PubMed pub. listing
Swamynathan Webpage
CBP Research Group(s):
CBMP Graduate Program Groups:
DNA Damage/Repair, Cell-Cycle Control and Gene Expression, Cancer
Cellular Injury, Wound Healing, Aging and Tissue Regeneration

Research Interest
Publications
  1. Swamynathan, S.K., Davis, J. and Piatigorsky, J. (2008). Identification of candidate KLF4 target genes reveals the molecular basis of the diverse regulatory roles of KLF4 in the mouse cornea. Invest. Ophthalmol. Vis. Sci. 49: 3360-3370.
  2. Kozmik, Z., Swamynathan, S.K., Ruzickova, J., Jonasova, K., Paces, C., Vlcek, C., and Piatigorsky, J. (2008). Cubozoan crystallins: Evidence for convergent evolution of Pax regulatory sequences. Evol. Dev. 10: 52-61.
  3. Swamynathan, S.K. and Piatigorsky, J. (2007) Regulation of the mouse aB-Crystallin and MKBP/HspB2 Promoter activities by shared and gene specific intergenic elements: The importance of context dependency. Int. J. Dev. Biol. 51: 689-700.
  4. Swamynathan, S.K., Katz, J.P., Kaestner, K.H., Ashery-Padan, R., Crawford, M.A. and Piatigorsky, J. (2007) Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Mol. Cell. Biol. 27: 182-194.
  5. Kanungo, J., Swamynathan, S.K., and Piatigorsky, J. (2004) Abundant Corneal Gelsolin in Zebrafish and the ‘Four-Eyed’ Fish, Anableps anableps: Possible Analogy with Multifunctional Lens Crystallins. Experimental Eye Res. 79: 949-956.
  6. Swamynathan, S.K., Crawford, M.A., Robison Jr, W.G., Kanungo, J and Piatigorsky, J. (2003). Adaptive differences in the structure and macromolecular compositions of the air and water corneas of the four-eyed fish (Anableps anableps). FASEB Journal 17: 1996-2005.
  7. Kanungo, J., Kozmik, Z, Swamynathan, S.K., and Piatigorsky, J. (2003) Gelsolin is a dorsalizing factor in zebrafish. Proc. Natl. Acad. Sci. USA. 100: 3287-3292.
  8. Swamynathan, S.K. and Piatigorsky, J. (2002) Orientation-dependent influence of an intergenic enhancer on the regulation of transcription of the divergently transcribed mouse shsp/aB-crystallin and MKBP/HSPB2 genes. J. Biol. Chem. 277: 49700-49706.