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CBP Faculty - Patrick H. Thibodeau, Ph.D.

Patrick H. Thibodeau, Ph.D.
Assistant Professor
Primary Appointment: Microbiology and Molecular Genetics
Tel: 412-383-8858
Fax: 412-648-8330
thibodea@pitt.edu
PubMed pub. listing
CBP Research Group(s):

CBMP Graduate Program Groups:
Cell Communication, Signaling and Ion Channel Biology
Genomics, Proteomics and Metabolomics

Research Interest
Publications
  1. Baker JM, Hudson RP, Kanelis V, Choy WY, Thibodeau PH, Thomas PJ, Forman-Kay JD. CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices. Nat Struct Mol Biol. 2007 Aug;14(8):738-45.
  2. Thibodeau PH, Brautigam CA, Machius M, Thomas PJ. Side chain and backbone contributions of Phe508 to CFTR folding. Nat Struct Mol Biol. 2005 Jan;12(1):10-6.
  3. Dorwart M, Thibodeau P, Thomas P. Cystic fibrosis: recent structural insights. J Cyst Fibros. 2004 Aug;3 Suppl 2:91-4. Review.
  4. Lewis HA, Buchanan SG, Burley SK, Conners K, Dickey M, Dorwart M, Fowler R, Gao X, Guggino WB, Hendrickson WA, Hunt JF, Kearins MC, Lorimer D, Maloney PC, Post KW, Rajashankar KR, Rutter ME, Sauder JM, Shriver S, Thibodeau PH, Thomas PJ, Zhang M, Zhao X, Emtage S. Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator. EMBO J. 2004 Jan 28;23(2):282-93.
  5. Zhang XM, Wang XT, Yue H, Leung SW, Thibodeau PH, Thomas PJ, Guggino SE. Organic solutes rescue the functional defect in delta F508 cystic fibrosis transmembrane conductance regulator. J Biol Chem. 2003 Dec 19;278(51):51232-42.
  6. Wigley WC, Corboy MJ, Cutler TD, Thibodeau PH, Oldan J, Lee MG, Rizo J, Hunt JF, Thomas PJ. A protein sequence that can encode native structure by disfavoring alternate conformations. Nat Struct Biol. 2002 May;9(5):381-8.