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CBP Faculty - William H. Walker, Ph.D.

William H. Walker, Ph.D.
Associate Professor
Primary Appointment: Obstetrics, Gynecology and Reproductive Sciences
Tel: 412-641-7672
Fax: 412-641-7676
walkerw@pitt.edu
PubMed pub. listing
Walker Webpage
CBP Research Group(s):
Reproductive Biology
CBMP Graduate Program Groups:
Reproductive Biology
DNA Damage/Repair, Cell-Cycle Control and Gene Expression, Cancer

Research Interest


Publications
  1. Shupe J, Cheng J, Puri P, Kostereva N, Walker WH. (2011) Regulation of Sertoli-germ Cell Adhesion and Sperm Release by FSH and Non-classical Testosterone Signaling. Molecular Endocrinology 25:238-252
  2. Wood MA, Walker WH. (2009) USF1/2 Transcription Factor DNA-binding Activity is Induced During Sertoli Cell Differentiation. Biology of Reproduction 80: 24-29.
  3. Viswanathan P, Wood, MA, Walker WH. (2009) FSH Transiently Blocks FSH Receptor Transcription by Increasing ID2 and Decreasing Upstream Stimulatory Factor (USF) Expression in Rat Sertoli Cells. Endocrinology (In Press)
  4. Thomas K, Wu J, Sung DY, Thompson W, Powell M, McCarrey J, Gibbs R. and Walker WH (2008) Sp1 transcription factors in male germ cell development and differentiation. Mol. Cell. Endocrinol. 19:2566-78.
  5. Cheng J, Watkins, SC, Walker, WH, (2007) Testosterone Activates MAP kinase and the EGF receptor in Sertoli cells. Endocrinology, 148: 2006-2074.
  6. Fix CA, Jordon C, Cano P, Walker WH, (2004) Androgen rapidly activates MAP kinase and the CREB transcription factor in Sertoli cells. Proc Nat Acad. Sci. USA 101: 10919-10924.
  7. Scobey J, Fix CA, Walker WH (2004) The Id2 Transcriptional Repressor Is Induced by Follicle-Stimulating Hormone and cAMP. J. Biol. Chem. 279:16064-16070.
  8. Delfino F, Boustead, JN, Walker WH (2003) NF-kB and tumor necrosis factor-alpha stimulate androgen receptor expression in Sertoli cells. Molecular Cellular Endocrinol. 201:1-12.
  9. Shell, SA, Fix, C, Olejniczak D, Gram-Humphry, N, Walker WH (2002) Regulation of CREB and Sp1 expression in the mammalian testis. Biol. Reprod. 66: 659-666.