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CBP Faculty - Alexander Sorkin, Ph.D.

Alexander Sorkin, Ph.D.
Richard Beatty Mellon Professor and Chair, Dept of Cell Biology
Tel: 412-624-3116
Fax: 412-648-8330
sorkin@pitt.edu
PubMed pub. listing
CBP Research Group(s):
Regulation of Channels and Transporters
Membrane Trafficking and Organelle Biogenesis
Regulation of Intracellular Signaling and Gene Expression
CBMP Graduate Program Groups:
Genomics, Proteomics and Metabolomics
Membrane Traffic of Proteins and Lipids

Research Interest
Publications
  1. Sorkin A, Duex JE. Quantitative analysis of endocytosis and turnover of epidermal growth factor (EGF) and EGF receptor. Curr Protoc Cell Biol. 2010 Mar;Chapter 15:Unit 15.14.
  2. Vina-Vilaseca A, Sorkin A. Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes. J Biol Chem. 2010 Mar 5;285(10):7645-56. Epub 2010 Jan 5.
  3. Sorkin A, von Zastrow M. Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol. 2009 Sep;10(9):609-22. Review.
  4. Price DA, Sorkin A, Zahniser NR. Cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity. Mol Pharmacol. 2009 Oct;76(4):812-23. Epub 2009 Jul 23.
  5. Zahniser NR, Sorkin A. Trafficking of dopamine transporters in psychostimulant actions. Semin Cell Dev Biol. 2009 Jun;20(4):411-7. Epub 2009 Jan 22. Review.
  6. Sorkin A, Goh LK. Endocytosis and intracellular trafficking of ErbBs. Exp Cell Res. 2009 Feb 15;315(4):683-96. Review.
  7. Duex JE, Sorkin A. RNA interference screen identifies Usp18 as a regulator of epidermal growth factor receptor synthesis. Mol Biol Cell. 2009 Mar;20(6):1833-44. Epub 2009 Jan 21.
  8. Sorkin A, Goh LK. Endocytosis and intracellular trafficking of ErbBs. Exp Cell Res. 2008 Oct 15;314(17):3093-106. Epub 2008 Aug 28. Review.
  9. Galperin E, Sorkin A. Endosomal targeting of MEK2 requires RAF, MEK kinase activity and clathrin-dependent endocytosis. Traffic. 2008 Sep;9(10):1776-90. Epub 2008 Jul 24.
  10. Sorkina T, Richards TL, Rao A, Zahniser NR, Sorkin A. Negative regulation of dopamine transporter endocytosis by membrane-proximal N-terminal residues. J Neurosci. 2009 Feb 4;29(5):1361-74.