Studies in this group aim at elucidating the physiological mechanisms underlying regulation of several ion channel and transporter proteins. Our approaches include biochemical, molecular, electrophysiologic, imaging, cell biologic and transgenic techniques. Inherited mutations in ion channels are responsible for many genetic diseases, including cystic fibrosis (CF). The department is home to a Translational Core Center in CF funded by the NIH and to a program grant from the CF Foundation.